| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1947317 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2016 | 10 Pages |
Abstract
•Anochetus emarginatus venom is mostly composed of disulfide-linked peptides.•U1-PONTX-Ae1a is a novel disulfide-linked peptide toxin with a unique 3D scaffold.•U1-PONTX-Ae1a has a β-hairpin motif with two antiparallel strands.•U1-PONTX-Ae1a reversibly paralyzes blowflies.•U1-PONTX-Ae1a inhibits human L-type voltage-gated calcium channels.
Keywords
TFA2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphatephenylthiohydantoinHBTUTriisopropylsilaneDIEAethanedithiolpTHnAChRTOFRP-HPLCDMFACNDTTDCMEDTESInuclear magnetic resonanceDMSOAcetonitrileTrifluoroacetic acidNMRmatrix-assisted laser desorption/ionizationdiisopropylethylaminedimethylformamideDichloromethanedithiothreitolDimethyl sulfoxideTime-of-Flight Ant venomMass spectrometryFerulic acidMALDINeurotoxinTIPSL-type calcium channelsliquid chromatographyreversed phase-high performance liquid chromatographyacetylcholine receptorelectrospray ionization
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