Differential scanning calorimetry as a complementary diagnostic tool for the evaluation of biological samples

Article ID	Journal	Published Year	Pages	File Type
1947338	Biochimica et Biophysica Acta (BBA) - General Subjects	2016	9 Pages	PDF

Abstract

DSC thermograms show sensitivity to changes in the bulk plasma proteome that correlate with clinical status. To move this technology towards clinical application the development of new approaches is needed to extract discriminatory parameters from DSC profiles for the comparison and diagnostic classification of patients. This article is part of a Special Issue entitled Microcalorimetry in the BioSciences - Principles and Applications, edited by Fadi Bou-Abdallah.

Keywords

DSC CPEX PLS PLS discriminant analysis PLS-DA tmax TFM ROC GLM AUC Smoothly clipped absolute deviation Linear discriminant analysis LDA Thermogram Least absolute shrinkage and selection operator Partial least squares Logistic regression Diagnostic classification Systemic lupus erythematosus SLE SVM Support vector machines Generalized linear model area under the curve principal component Plasma proteome Differential scanning calorimetry Scad LASSO receiver operating characteristic