Redox-regulated fate of neural stem progenitor cells

Article ID	Journal	Published Year	Pages	File Type
1947436	Biochimica et Biophysica Acta (BBA) - General Subjects	2015	12 Pages	PDF

Abstract

Increasing knowledge of temporary and spatially defined redox regulation is of high relevance for the development of novel approaches in the field of cell-based regeneration of nervous tissue in various pathological states. This article is part of a special issue entitled Redox regulation of differentiation and de-differentiation.

Keywords

TBX3 EGFR PI3K PARP-1 GFAP NADP Nrf2 GSH GST HO-1 DVL RMS GSSG RNS SIRT sirtuin GSK-3β HIF-1α FGF2 bHLH NSCs SGZ SVZ Nrx Heme oxygenase-1 PcG Oct4 Sox2 NSPCs Trx HGF TGFβ1 GCLC PDGFR GPx1 NeuroD1 B lymphoma Mo-MLV insertion region 1 homolog FIP200 PRX GRx PRDM16 MASH1 PAX nucleoredoxin Paired box gene VCAM1 dual oxidases Bmi1 dll4 ERK1/2 MAPK NAD(P)H:quinone oxidoreductase NOx ROS basic helix-loop-helix NADPH oxidase disheveled transforming growth factor beta 1 Differentiation thioredoxin rostral migratory stream forkhead Box O Self-renewal PR domain containing 16 Redox SOD Neural stem and progenitor cells Embryonic stem cells Neural stem cells Superoxide dismutase fibroblast growth factor 2 Hepatocyte growth factor antioxidant response element T-box transcription factor octamer-binding transcription factor 4 nuclear factor erythroid 2-related factor 2 FoxO phosphoinositide-3-kinase subgranular zone subventricular zone Sex determining region Y-box 2 Vascular cell adhesion molecule 1 NAD Hes1 ARE hypoxia inducible factor-1 alpha Glial fibrillary acidic protein Peroxiredoxin extracellular-signal-regulated kinase 1/2 mitogen-activated protein kinases polycomb group Glutathione glutathione-S-transferase glutathione disulfide glutathione peroxidase 1 Glutaredoxin glycogen synthase kinase-3 beta reactive nitrogen species Reactive oxygen species platelet-derived growth factor receptor Epidermal growth factor receptor