Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K+ channels in cerebellum granular cells

We report the first example of a Kv4 subfamily potassium channel blocked by discrepin and identify the amino acid residues responsible for the blockage. The availability of discrepin variant peptides stimulates further research on the functions and pharmacology of neuronal Kv4 channels and on their possible roles in neurodegenerative disorders.