Regulation of DNA repair by S-nitrosylation

Article ID	Journal	Published Year	Pages	File Type
1947709	Biochimica et Biophysica Acta (BBA) - General Subjects	2012	6 Pages	PDF

Abstract

âºNO/RNS can directly or indirectly cause DNA mutation. âºKey DNA repair proteins AGT, Ogg1, APE1, and DNA-PKcs are targets of S-nitrosylation. âºS-nitrosylation modulates DNA repair protein activity, stability, and localization. âºS-nitrosylation levels depend on NO synthesis by NOS and denitrosylation by GSNOR. âºGSNOR deficiency leads to nitrosative inactivation of AGT and hepatocarcinogenesis.

Keywords

S-nitrosoglutathione GSNO reductase O6-alkylguanine-DNA-alkyltransferase DNA repair proteins AP endonuclease 1 GSNOR S-nitrosylation APE1 DNA-PKcs OGG1 8-oxoG S-nitrosothiol SNO GSNO NO synthase Den DSB LPS RNS NOS DTT BER GAPDH 8-oxoguanine NER HCC Nitrosative stress inflammation nucleotide excision repair base excision repair diethylnitrosamine dithiothreitol Carcinogenesis double-strand break Zinc lipopolysaccharide Nitric oxide AGT DNA-dependent protein kinase catalytic subunit Hepatocellular carcinoma glyceraldehyde-3-phosphate dehydrogenase reactive nitrogen species