S-nitrosylation of surfactant protein D as a modulator of pulmonary inflammation

Article ID	Journal	Published Year	Pages	File Type
1947713	Biochimica et Biophysica Acta (BBA) - General Subjects	2012	7 Pages	PDF

Abstract

âº Multimerization of SP-D is a critical feature of its function. âº NO is capable of modifying SP-D through S-nitrosylation. âº S-nitrosylation of SP-D causes disruption of its quaternary structure into trimers. âº The formation of SNO-SP-D trimers initiates a pro-inflammatory response. âº Disruption of SP-D multimeric state causes a loss of its anti-inflammatory function.

Keywords

S-nitrosothiol myeloid differentiation protein 88 TAB2 TAB1 MD-2 SP-D TAK1 SHP-1 ARDS NF-κB SNO IL-1 receptor associated kinase TRAF6 MBL LBP LPS MYD88 IKK IκB TLR IκB kinase MAPK Acute lung injury Pulmonary inflammation Ali Chronic obstructive pulmonary disease COPD toll like receptor TIR Toll-like receptor Acute respiratory distress syndrome myeloid differentiation factor 2 TNF receptor associated factor IRAK nuclear factor kappa B Mannose-binding lectin inhibitor of NF-κB Nitric oxide Surfactant protein D LPS-binding protein mitogen-activated protein kinase