Nitroalkylation — A redox sensitive signaling pathway

Redox-sensitive posttranslational modification emerged as important signaling mechanisms. Besides other posttranslational modifications nitroalkylation by nitrated fatty acids mediate favorable anti-inflammatory effects. This review gives an overview of the generation and the reactivity of nitrated fatty acids. Additionally, it provides insights into the so far described pathways regulated by nitrated fatty acids. This article is part of a Special Issue entitled Regulation of Cellular Processes by S-nitrosylation.

Research highlights► We give an overview of the generation and the reactivity of nitrated fatty acids. ► Redox-sensitive post-translational modification (nitroalkylation) of fatty acids serves as important signaling mechanism. ► Nitrated fatty acids are potent anti-inflammatory lipid signaling mediators. ► Pathways regulated by nitrated fatty acids.