| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1947729 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2011 | 10 Pages |
Abstract
⺠Long-term adaptation of rat brain cortex to morphine (10 days). ⺠Increased amount of ACI (8x) and II (2.5x) in plasma-membrane fraction (PM). ⺠Unchanged amount of prototypical PM marker Na, K-ATPase. ⺠20 days since the last dose density of ACI and II in PM returns to the control level.
Keywords
PTXheterotrimeric guanine nucleotide-binding regulatory proteinsw.w.Long-term adaptationSLBGsαβ-ARPBSGPCRMORTBSPMSFDAMGONa,K-ATPase[35S]GTPγSδ-Opioid receptorμ-Opioid receptoradenylyl cyclaseTris-buffered salineDADLEDORpertussis toxinPlasma membraneinorganic phosphatephenylmethylsulfonyl fluoridePhosphate-buffered salinemorphinewet weightKORG proteinsβ-Adrenergic receptorκ-opioid receptorOpioid receptorG protein-coupled receptor
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Authors
Hana Ujcikova, Katerina Dlouha, Lenka Roubalova, Miroslava Vosahlikova, Dmytro Kagan, Petr Svoboda,