| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1947767 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 9 Pages |
Abstract
⺠AGEs elicit oxidative stress generation and subsequently cause inflammatory and thrombogenic reactions via interaction with a receptor for AGEs (RAGE). ⺠Mitochondrial superoxide generation plays an important role in the formation and accumulation of AGEs under diabetic conditions. ⺠A pathophysiological crosstalk between AGE-RAGE axis and renin-angiotensin system could contribute to vascular complications in diabetes. ⺠Inhibition of AGEs-RAGE-oxidative stress system is a therapeutic target for preventing vascular complications in diabetes.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Sho-ichi Yamagishi, Sayaka Maeda, Takanori Matsui, Seiji Ueda, Kei Fukami, Seiya Okuda,