Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1947779 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2012 | 8 Pages |
Abstract
⺠We describe the design, synthesis and biological activities of MHY384. ⺠The depigmentary effect of MHY384 results from down-regulation of MITF. ⺠MHY384 can suppress the production of melanin. ⺠MHY384 can be an effective skin-whitening agent.
Keywords
Mc1rHClCDCl3FBSDMEMCBPCREBnuclear magnetic resonance3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidecAMPDMSOl-3,4-dihydroxyphenylalaninel-DOPADulbecco's modified Eagle's mediumMTTCyclic adenosine monophosphateanalysis of varianceANOVANMRCarbon dioxideDimethyl sulfoxidefetal bovine serumCREB-binding proteincAMP responsive element binding proteinCO2Deuterated chloroformHydrogen chloride
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Authors
Yu Kyeong Han, Yun Jung Park, Young Mi Ha, Daeui Park, Ji Yeon Lee, Naree Lee, Jeong Hyun Yoon, Hyung Ryong Moon, Hae Young Chung,