Protective effects of allopurinol against acute liver damage and cirrhosis induced by carbon tetrachloride: Modulation of NF-κB, cytokine production and oxidative stress

► Allopurinol protects against necrosis regardless of dose and exposure time with CCl4. ► Allopurinol maintained redox balance both hydrophilic and lipophilic induced by CCl4. ► Allopurinol inhibited partially the nuclear translocation of NF-κB. ► Allopurinol showed immunomodulatory effects on pro- and anti-inflammatory cytokines. ► Allopurinol reduces fibrosis by decreased TGF-β expression couple induce MMP-13.