Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1948470 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2007 | 4 Pages |
Abstract
We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (<Â 100Â nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.
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Authors
Monia Monti, Mirko Pinotti, Giovanni Appendino, Franco Dallocchio, Tiziana Bellini, Fabiana Antognoni, Ferruccio Poli, Francesco Bernardi,