| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1948793 | Biochimica et Biophysica Acta (BBA) - General Subjects | 2006 | 9 Pages |
Abstract
Oxidative damage to protein has been implicated in a number of diseases. Much interest has been focused on preventing oxidative damage to protein. Here we showed that hydroxycinnamic acid derivatives (HCA) were able to inhibit the cross-linking of protein induced by riboflavin-mediated photooxidation. HCA were also found to strongly protect lysozyme from gamma rays irradiation. The antioxidative properties of HCA were further studied by laser flash photolysis. Mechanism of antioxidant activities of HCA on lysozyme oxidation was discussed. HCA were found to protect protein against oxidation by scavenging oxidizing species and repairing the damaged protein.
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Authors
Hongping Zhu, Shimou Chen, Shumei Hao, Zhaoxia Zhang, Wenfeng Wang, Side Yao,