Article ID Journal Published Year Pages File Type
1949133 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2015 10 Pages PDF
Abstract

•Bio- and chemical syntheses of non-enzymatic cyclic oxygenated derivatives of PUFA are presented.•Current evaluation of iso-prostanoids and furanoids in vivo is discussed.•Biological activities of those PUFA metabolites are compared.

Cyclic oxygenated metabolites are formed in vivo through non-enzymatic free radical reaction of n-6 and n-3 polyunsaturated fatty acids (PUFAs) such as arachidonic (ARA C20:4 n-6), adrenic (AdA 22:4 n-6), α-linolenic (ALA 18:3 n-3), eicosapentaenoic (EPA 20:5 n-3) and docosahexaenoic (DHA 22:6 n-3) acids. These cyclic compounds are known as isoprostanes, neuroprostanes, dihomo-isoprostanes and phytoprostanes. Evidence has emerged for their use as biomarkers of oxidative stress and, more recently, the n-3PUFA-derived compounds have been shown to mediate bioactivities as secondary messengers. Accordingly, this review will focus on the cyclic oxygenated metabolites generated from AdA, ALA, EPA and DHA. This article is part of a Special Issue entitled “Oxygenated metabolism of PUFA: analysis and biological relevance”.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
, , , , , , ,