| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1949384 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 9 Pages |
Abstract
⺠SIRT1 was reduced and PPARβ/δ increased in adipose tissue from obese patients. ⺠Stimulation of human adipocytes with TNF-α caused similar changes. ⺠TNF-α effects were inhibited by an NF-κB inhibitor and the PPARβ/δ agonist GW501516. ⺠These TNF-α effects can help perpetuate the inflammatory process in human adipocytes.
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Authors
LucÃa Serrano-Marco, Matilde R. Chacón, Elsa Maymó-Masip, Emma Barroso, Laia Salvadó, Martin Wabitsch, Lourdes Garrido-Sánchez, Francisco J. Tinahones, Xavier Palomer, Joan Vendrell, Manuel Vázquez-Carrera,