| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1949392 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 9 Pages |
Abstract
⺠24,25EC regulates DHCR24, with accumulation of desmosterol, decreasing cholesterol. ⺠DHCR24 inhibition was specific to C-25 oxygenated side-chain oxysterols. ⺠Manipulating endogenous levels of 24,25EC was sufficient to reduce DHCR24 activity. ⺠DHCR24, an important enzyme in human health, is post-transcriptionally regulated.
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Authors
Eser J. Zerenturk, Ika Kristiana, Saloni Gill, Andrew J. Brown,