Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

Article ID	Journal	Published Year	Pages	File Type
1949406	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids	2012	10 Pages	PDF

Abstract

âº Cellular cholesterol homeostasis is a tightly regulated process. âº Mutations in many proteins involved in cholesterol homeostasis result in disease. âº Specific role and substrate of ABCG1 are still unknown. âº This review explores new insights into ABCG1 structure and function.

Keywords

SR-B1 LXR VDR FXR TLR4 RXR SREBP Retinoid X receptor HMG-CoA PXR scavenger receptor B1 PCSK9 NPC2 NPC1 eNOS LDLR 3-hydroxy-3-methyl-glutaryl-CoA ABC LRP8 GPS2 AICAR TNFα CETP HDL MCP-1 ApoER2 SCAP ICAM-1 ABC transporter farnesoid X receptor BAC Apoe apolipoprotein E Sterols hydroxyeicosatetraenoic acid Idol Insig tumor necrosis factor α endothelial nitric oxide synthase high density lipoprotein low density lipoprotein LDL MicroRNA HETE monocyte chemotactic protein 1 sterol regulatory element binding protein cholesterol ester transfer protein srebp cleavage-activating protein Proprotein convertase subtilisin/kexin type 9 Insulin Induced Gene liver X receptor bacterial artificial chromosome cholesterol ATP binding cassette Androgen Receptor Estrogen receptor Toll-like receptor 4 Lipoprotein receptor low density lipoprotein receptor Mineralocorticoid receptor Vitamin D receptor Progesterone receptor Pregnane X receptor glucocorticoid receptor