| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1949416 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 9 Pages |
Abstract
⺠Interhelical salt bridges for the HDL belt model maximize at wheel position (wp) 9. ⺠Only wp9 lies directly in the contact edge between helical rings. ⺠Wp9 was mutated to Cys and kept under reducing conditions during disc formation. ⺠We show that helix 5, under certain conditions, progresses to a full hinged domain. ⺠We hypothesize that, upon binding of LCAT, helix 5 forms a full hinged domain.
Keywords
SDSdimyristoylphosphatidylcholineLCATPoPCVMDHDLApoA-IdMPCreconstituted HDLSite-directed mutagenesisapoapolipoproteincrosslinkingFourier-transform infrared spectroscopyMolecular dynamicsvisual molecular dynamicssodium dodecylsulfateMolecular dynamics simulationPhospholipidhigh density lipoproteinsMolecular modelingPalmitoyloleoylphosphatidylcholine
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Authors
Ling Li, Songlin Li, Martin K. Jones, Jere P. Segrest,