| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1949435 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 7 Pages |
Abstract
⺠FAPP2 contains a PtdIns4P (and ARF1) binding PH domain and a GLTP (Glycolipid Transfer Protein) domain. ⺠The FAPP2-PH domain targets the protein to the trans-Golgi network and has membrane bending activity. ⺠Via the GLTP domain FAPP2 transfers glucosylceramide and fosters complex glycolipid synthesis at the Golgi complex. ⺠FAPP2 controls TGN-to-plasma membrane vesicular trafficking by assisting the formation of post-Golgi carriers. ⺠The lipid-transfer activity of FAPP2 is required for its role in membrane trafficking.
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Authors
Giovanni D'Angelo, Laura Rita Rega, Maria Antonietta De Matteis,