Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1949451 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 10 Pages |
Abstract
⺠We studied the impact of membrane trans fatty acids incorporation on cholesterol efflux from mouse and human macrophages. ⺠The industrially produced trans elaidic acid specifically reduced ABCA1 cholesterol efflux pathway. ⺠The naturally produced trans vaccenic acid had no impact on cholesterol efflux. ⺠In both cellular models, these deleterious effects were observed in cholesterol-normal or cholesterol-loaded macrophages. ⺠Elaidic acid may contribute to atherogenesis by impairing the ABCA1 cholesterol efflux pathway in macrophages.
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Authors
Natalie Fournier, Nesrine Attia, Delphine Rousseau-Ralliard, Benoît Vedie, Frédéric Destaillats, Alain Grynberg, Jean-Louis Paul,