| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1949454 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 | 8 Pages |
Abstract
⺠Direct modulation of clusterin expression by Cox-2. ⺠Pre-secretory/secretory and pre-nuclear clusterin isoforms upregulated. ⺠Cox-2-dependent clusterin was normally processed and secreted. ⺠Cox-2 induced clusterin via activation of HSF1 and PPARγ. ⺠Cox-2/15d-PGJ2, but not clusterin, inhibited NF-κB signalling at the nuclear level.
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Authors
Damien Gates, Kiera Dollin, Roisin Connolly, Ian Young, Lesley Powell, Jane McEneny, Martin Gleave, Ann McGinty,