Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1949469 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 | 7 Pages |
Abstract
⺠LXR agonist and saturated fat ingestion lead to hepatic steatosis and dysfunction. ⺠nâ3 fatty acids decrease LXR agonist-mediated hepatic steatosis. ⺠This is linked to decreasing hepatic SREBP-1c and fatty acid synthase mRNA. ⺠nâ3 diet also normalizes LXR agonist-mediated increases of hepatotoxicity.
Keywords
PPARNAFLDLXR agonistalanine aminotrasferaseChREBPLXRSREBP-1cALTSATFFAFASCYP7A1ASTHepatic dysfunctionHepatic steatosisFatty acidFree fatty acidfatty acid synthasenon-alcoholic fatty liver diseasesknockoutsaturated fatliver X receptorcarbohydrate-responsive element-binding proteincholesterol 7α-hydroxylaseperoxisome proliferators-activated receptor
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Authors
Un Ju Jung, Peri N. Millman, Alan R. Tall, Richard J. Deckelbaum,