| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1949507 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 | 15 Pages |
Abstract
⺠DESI-MS is a powerful and sensitive ambient MS ionization method. ⺠2D and 3D imaging of lipids from untreated biological samples is achieved by DESI-MS under ambient conditions. ⺠DESI-MS has strengths and limitations for lipid characterization and imaging. ⺠DESI-MS technical workflow and a survey of applications are described. ⺠Discussion on lipid mapping and biomarker discovery and a perspective on the future of DESI imaging are included.
Keywords
LAESIDHSMHSTglycerophosphoserineGalCerDESI-MSRCCGBMPLS-DALPCDihydrosphingomyelinTLCH&EPCAsphingolipidssphingomyelinFatty acidsTAGsPartial least squares discriminant analysisPrincipal component analysisTriacylglyceridesDisease DiagnosisImagingdiacylglycerolsDAGReimsSulfatidesSIMSAmbient mass spectrometrysecondary ion mass spectrometryLitlaser ablation electrospray ionizationLipidomicsmatrix assisted laser desorption ionizationMALDIHematoxylin and EosinRenal cell carcinomahigh performance liquid chromatographyHPLCthin-layer chromatographyGas chromatographycholesteryl estersglycerophospholipidsglycerophosphocholineGlycerolipidsGlioblastomadesorption electrospray ionization
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Authors
Livia S. Eberlin, Christina R. Ferreira, Allison L. Dill, Demian R. Ifa, R. Graham Cooks,