| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1949510 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 | 15 Pages |
Abstract
⺠Recent instrumental and sample preparation methodologicaladvances achieved in ToF- SIMS, as well as the successful applications of these advances in the detection of lipid from biological material are described in this review. ⺠The performance of ToF-SIMS in the analysis of lipids is compared to similar imaging techniques, including MALDI, DESI and dynamic SIMS. ⺠Various lipid species detected and identified using ToF-SIMS are compiled in tables and organized using the lipid classification system established by the Lipid MAPS consortium. ⺠State-of-the-art ToF-SIMS instruments, the J105 3D Chemical Imager and C60+-QSTAR, are described and their potential application in the field of lipidomics is discussed.
Keywords
LC-MSsecondary electron microscopyIndium tinoxideDESISIADPPCTLCPLAIMSCIDTof-SIMSSample preparationsphingomyelinOctITOTemIndiumTAGsFast atom bombardmentcollision induced dissociationDC, Direct currentcutting temperatureSIMSimaging mass spectrometryTime-of-Flight Secondary Ion Mass Spectrometrysecondary ion mass spectrometryLiquid chromatography mass spectrometryFabphospholipase ALipidMALDIMetaSEMCluster sourceTransmission electron microscopyGalliumglycerophosphoethanolaminedesorption electrospray ionizationmatrix-assisted laser desorption ionization
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Authors
Melissa K. Passarelli, Nicholas Winograd,