Article ID Journal Published Year Pages File Type
1949589 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2010 6 Pages PDF
Abstract
►In NS0 cells, unlike in yeast, 3-ketoreductase does not assist oxidosqualene cyclase. ►Mouse and human 3-ketoreductases are catalytically active in yeast. ►Mouse and human 3-ketoreductases do not assist yeast oxidosqualene cyclase. ►When, from yeasts to mammals, the reductase-cyclase interaction was lost?
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts
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