Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1949660 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2010 | 5 Pages |
Abstract
Lipoprotein remodelling in the periphery has been extensively studied. For example, the processing of nascent apoAI particles to cholesterol-loaded HDL lipoproteins during reverse cholesterol transport involves a series of enzymes, transporters in peripheral tissue, as well as other apolipoproteins and lipoproteins. These extensive modifications and interconversions are well defined. Here, we present the hypothesis that a similar process occurs within the blood brain barrier (BBB) via glia-secreted lipid-poor apoE particles undergoing remodelling to become mature central nervous system (CNS) lipoproteins. We further pose several pressing issues and future directions for the study of lipoproteins in the brain.
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Authors
Chunjiang Yu, Katherine L. Youmans, Mary J. LaDu,