| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1949835 | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2009 | 5 Pages |
Abstract
The discovery that Arf GTPases, mediators of membrane traffic, activate phospholipase D (PLD) raised the possibility that Arfs could facilitate membrane traffic by altering membrane lipid composition. PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. This review examines studies that have reported a role for PLD in endocytosis and membrane recycling from endocytic pathways.
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Authors
Julie G. Donaldson,