Article ID Journal Published Year Pages File Type
1950015 Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2008 39 Pages PDF
Abstract

Much is known about the pathways that control the biosynthesis, transport and degradation of sphingolipids. During the last two decades, considerable progress has been made regarding the roles this complex group of lipids play in maintaining membrane integrity and modulating responses to numerous signals. Further novel insights have been provided by the analysis of newly discovered genetic diseases in humans as well as in animal models harboring mutations in the genes whose products control sphingolipid metabolism and action. Through the description of the phenotypic consequences of genetic defects resulting in the loss of activity of the many proteins that synthesize, transport, bind, or degrade sphingolipids, this review summarizes the (patho)physiological functions of these lipids.

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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