Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1950547 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2014 | 11 Pages |
•Mitochondria and ER are tethered.•Tethering controls multiple mitochondrial and ER functions.•Molecules involved in tethering are being discovered and characterized.
The interface between mitochondria and the endoplasmic reticulum is emerging as a crucial hub for calcium signalling, apoptosis, autophagy and lipid biosynthesis, with far reaching implications in cell life and death and in the regulation of mitochondrial and endoplasmic reticulum function. Here we review our current knowledge on the structural and functional aspects of this interorganellar juxtaposition. This article is part of a Special Issue entitled: Calcium Signaling In Health and Disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.