Article ID Journal Published Year Pages File Type
1951763 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2006 9 Pages PDF
Abstract

In mammalian cells, there is an extensive and continuous exchange of mitochondrial DNA (mtDNA) and its products between mitochondria. This mitochondrial complementation prevents individuals from expression of respiration deficiency caused by mutant mtDNAs. Thus, the presence of mitochondrial complementation does not support the generally accepted mitochondrial theory of aging, which proposes that accumulation of somatic mutations in mtDNA is responsible for age-associated mitochondrial dysfunction. Moreover, the presence of mitochondrial complementation enables gene therapy for mitochondrial diseases using nuclear transplantation of zygotes.

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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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