Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression ofÂ NF-ÎºB signaling

Article ID	Journal	Published Year	Pages	File Type
1952000	Biochimie	2015	12 Pages	PDF

Keywords

BMC IKK AP-1 IκB M-CSF TRAP MNCs PPAR CTR BMD ERK RANKL GAPDH IC50 STAT3 ROI NF-κB TGF-β Titanium particle DC-STAMP NFATc1 UHMWPE Jnk Osteolysis BMMs BV/TV c-Jun N-terminal kinase IκB kinase MAPKs Osteoclastogenesis Ursolic acid tartrate-resistant acid phosphatase transforming growth factor-β Bone mineral density computed tomography Titanium bone volume/tissue volume Multinucleated cells nuclear factor-κB macrophage-colony stimulating factor signal transducer and activator of transcription 3 Bone mineral content region of interest inhibitor of NF-κB half-maximal inhibitory concentration polymerase chain reaction PCR activator protein-1 dendritic cell-specific transmembrane protein PMMA Ultrahigh molecular weight polyethylene polymethyl methacrylate Cathepsin K extracellular signal-regulated kinase mitogen-activated protein kinases glyceraldehyde-3-phosphate dehydrogenase peroxisome proliferator-activated receptor calcitonin receptor receptor activator of nuclear factor-κB ligand

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression ofÂ NF-ÎºB signaling

Authors

Chuan Jiang, Fei Xiao, Xinfeng Gu, Zanjing Zhai, Xuqiang Liu, Wengang Wang, Tingting Tang, You Wang, Zhenan Zhu, Kerong Dai, An Qin, Jinwu Wang,