| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1952260 | Biochimie | 2011 | 7 Pages |
Abstract
⺠We compared E1A/c-Ha-Ras-transformed wild-type and p21Waf1-null MEFs. ⺠p21â/â cells are not completely transformed, retain fibroblast-like morphology. ⺠p21â/â cells have actin stress fibers and show reduced migration and invasion. ⺠Actin depolymerization correlates with partial cytoplasmic retention of p21Waf1. ⺠Cytoplasmic p21Waf1 is likely to be required for complete transformation of MEFs.
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Authors
Vasily S. Romanov, Alexander A. Bardin, Svetlana G. Zubova, Tatiana V. Bykova, Valery A. Pospelov, Tatiana V. Pospelova,