| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1952267 | Biochimie | 2011 | 11 Pages |
Abstract
⺠AKR1B14 metabolizes cytotoxic aldehydes and prostaglandin H2. ⺠We find that bile acids significantly activate the activity of AKR1B14. ⺠Bile acid accelerates the NADP+ dissociation, rate-limiting step of the catalysis. ⺠Bile acid interacts with His269 and facilitates the NADP+ release.
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Authors
Satoshi Endo, Toshiyuki Matsunaga, Anna Fujita, Tsukasa Kuragano, Midori Soda, Krithika Sundaram, Urmi Dhagat, Kazuo Tajima, Ossama El-Kabbani, Akira Hara,