Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1952314 | Biochimie | 2009 | 11 Pages |
Abstract
Overall, we show that the reduced peroxisomal β-oxidation of fat observed in Thb null mice fed Wy is associated with enhanced hepatic lipogenesis, through the combined elevation of microsomal SCD1 protein and activity. Ultimately, not only the amount but also the quality of the hepatic fatty acid pool is modulated upon the deletion of Thb.
Keywords
THBWy14,643VLCFAsLCFAsMUFAsstearoyl-CoA desaturase-1SREBPsFasTHAPUFAsPPARαperoxisome proliferator-activated receptor alphasaturated fatty acidsmono-unsaturated fatty acidspoly-unsaturated fatty acidsvery-long-chain fatty acidsLong-chain fatty acidsFatty acid oxidationTriglyceridesFAOsterol response element binding protein
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Authors
Ségolène Arnauld, Marco Fidaleo, Marie-Claude Clémencet, Grégory Chevillard, Anne Athias, Joseph Gresti, Ronald J. Wanders, Norbert Latruffe, Valérie Nicolas-Francès, Stéphane Mandard,