| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1952533 | Biochimie | 2011 | 11 Pages |
Abstract
⺠We found an increased intracellular Ca2+ in COPD patients as compared to healthy. ⺠Increased PKC levels and iNOS/eNOS imbalance also correlated with COPD severity. ⺠Altered parameters were found normalized by a novel Ca2+ channel blocker, H-DHPM. ⺠H-DHPM effectively increased eNOS levels by releasing it from caveolin bound form. ⺠The effects of H-DHPM were found comparative to amlodipine.
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Authors
Sushma Manral, Sumati Bhatia, Rajesh Sinha, Ajit Kumar, Vishwajeet Rohil, Anu Arya, Ashish Dhawan, Pragya Arya, Rini Joshi, Sreerama C. Sreedhara, Sukanya Gangopadhyay, Surendra K. Bansal, Suvro Chatterjee, Nabo K. Chaudhury, Vannan K. Vijayan,