| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1952643 | Biochimie | 2011 | 9 Pages |
Abstract
âºPhysical sites of interaction between PAC1 receptor (PAC1-R) and PACAP are defined. âºExtracellular N-terminal domain of PAC1-R is the major binding site of PACAP. âºN-terminus of PACAP attaches to the Ser98 - Met111 segment of PAC1-R. âºAmino acid at position 6 of PACAP labels the Ser124 - Glu125 dipeptide of PAC1-R. âºResidue 22 of PACAP has a contact point in the Ser141 - Met172 segment of PAC1-R.
Keywords
SARpeptide N-glycanase FPAC1-RN-chlorosuccinimidebiphenylalanineCNBrNOEpTHGIPGLP-1PACAPGHRHBPAVIPNCSBiPG protein-coupled receptorsSodium dodecylsulfate-polyacrylamide gel electrophoresisSDS-PAGEChocyanogen bromideChinese Hamster OvaryextracellularStructure–activity relationshipstransmembraneBinding sitesNlenorleucinePhotoaffinity labelinggrowth hormone-releasing hormoneparathyroid hormonegastric inhibitory polypeptidepituitary adenylate cyclase-activating polypeptidevasoactive intestinal peptideglucagon-like peptide 1PAC1 receptor
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Authors
Agnieszka Dejda, Steve Bourgault, Ngoc Duc Doan, Myriam Létourneau, Alain Couvineau, Hubert Vaudry, David Vaudry, Alain Fournier,