Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1953370 | Biochimie | 2007 | 6 Pages |
Abstract
IL-28 and IL-29 were recently described as members of a new cytokine family that shares with type I interferon (IFN) the same Jak/Stat signalling pathway driving expression of a common set of genes. Accordingly, they have been named IFNλ. IFNsλ exhibit several common features with type I IFNs: antiviral activity, antiproliferative activity and in vivo antitumour activity. Importantly, however, IFNsλ bind to a distinct membrane receptor, composed of IFNLR1 and IL10R2. This specific receptor usage suggests that this cytokine family does not merely replicate the type I IFN system and justifies its designation as type III IFN by the nomenclature committee of the International Society of Interferon and Cytokine Research.
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Authors
Gilles Uzé, Danièle Monneron,