Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1953373 | Biochimie | 2007 | 7 Pages |
Abstract
TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses.
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Authors
Takashi Fujita, Kazuhide Onoguchi, Koji Onomoto, Reiko Hirai, Mitsutoshi Yoneyama,