Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1953385 | Biochimie | 2007 | 6 Pages |
Abstract
Interferon-γ is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-γ after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR.
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Authors
Mathieu Bonmort, Evelyn Ullrich, Grégoire Mignot, Bénédikt Jacobs, Nathalie Chaput, Laurence Zitvogel,