Article ID Journal Published Year Pages File Type
1953415 Biochimie 2007 9 Pages PDF
Abstract

Reverse gyrase was discovered more than twenty years ago. Recent biochemical and structural results have greatly enhanced our understanding of their positive supercoiling mechanism. In addition to new biochemical properties, a fine tuning of reverse gyrase regulation in response to DNA damaging agents has been recently described. These data give us a new insight in the cellular role of reverse gyrase. Moreover, it has been proposed that reverse gyrase has been implicated in genome stability.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Authors
,