Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1953474 | Biochimie | 2007 | 5 Pages |
Abstract
Sialic acids from the erythrocyte (RBC) membrane of a patient suffering from polycythemia vera, a malignant orphan disorder of hematopoietic cells, was studied using GC/MS. We found that the sialic acid diversity of these membranes was drastically reduced since only four entities were identified: Neu5Ac (91.5%) and its 1,7 lactone Neu5Ac1,7L (7.5%) which is absent in normal RBC, Neu4,5Ac2 (0.50%) and Neu4,5Ac2 9Lt (0.50%); in normal RBC, Neu5,7Ac2, Neu5,9Ac2, Neu5Ac9Lt, Neu5Ac8S and Neu, as well as traces of Kdn, were also present. Neu5Gc and its O-alkylated or O-acetylated derivatives, which are considered by various authors as cancer markers, were not detected.
Keywords
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Authors
Daniela Bratosin, Carmen Palii, Andreea Delia Moicean, Jean-Pierre Zanetta, Jean Montreuil,