| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1958420 | Biophysical Journal | 2007 | 6 Pages |
Abstract
The need for low-cost DNA sequence detection in clinical applications is driving development of new technologies. We demonstrate a method for detection of mutations in a DNA sequence purely by electronic means, and without need for fluorescent labeling. Our method uses an array of nanopores to perform synchronized single-molecule force spectroscopy measurements over many molecules in parallel, yielding detailed information on the kinetics of hundreds of molecule dissociations in a single measurement.
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Authors
Carolina Tropini, Andre Marziali,