Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1960048 | Biophysical Journal | 2005 | 9 Pages |
Abstract
In this article, we explore the information content of molecular force-field calculations. We make use of exhaustive lattice models of molecular conformations and reduced alphabet sequences to determine the relative resolving power of pairwise interaction-based force fields. We find that sequence-specific interactions that operate over longer distances offer greater amounts of information than nearest-neighbor or non-sequence-specific interactions. In a companion article in this issue, we explored the information content of sequence alignment procedures and the calculation of gap penalties. Both articles have implications for protein and nucleic-acid computations.
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Authors
Tiba Aynechi, Irwin D. Kuntz,