Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1960194 | Biophysical Journal | 2006 | 9 Pages |
Abstract
Poly-L-lysine-induced morphological changes in liquid phase supported bilayers consisting of mixed anionic/zwitterionic and neat zwitterionic headgroup phospholipids were studied with atomic force microscopy and epifluorescence microscopy. Results obtained from these studies indicate that poly-L-lysine can induce domains, defects, and aggregate structures on both mixed bilayers and strictly zwitterionic bilayers. The structures formed on liquid phase supported bilayers were observed to be immobile from a timescale of 50 ms to several minutes. We propose that poly-L-lysine of sufficient length interacts with the mica substrate and phospholipids to create the stationary structures noted.
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Authors
Tighe A. Spurlin, Andrew A. Gewirth,