| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1963521 | Cellular Signalling | 2013 | 8 Pages |
Abstract
⺠IL-1β induces HLA-G and TLR4 expression in a HIF-1α dependent manner in glioma. ⺠IL-1β induces HMGB1-TLR4 axis, and this axis regulates HLA-G expression. ⺠GBM tumors possess elevated HMGB1 and β-defensin-3. ⺠hBD3 inhibits IL-1β induced HLA-G, TLR4, HMGB1 expression. ⺠hBD3 abrogates IL-1β induced pro-inflammatory mediators.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Piyushi Gupta, Sadashib Ghosh, Ashwat Nagarajan, Veer Singh Mehta, Ellora Sen,