Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1963542 | Cellular Signalling | 2013 | 11 Pages |
Abstract
⺠Injury-induced corneal opacification depends on CB1 blunting of TRPV1 activation. ⺠Protein-protein interaction between CB1 and TRPV1 desensitizes TRPV1 activation. ⺠Desensitizing TRPV1 suppresses signaling events mediating fibrosis and inflammation. ⺠CB1 activation may be a novel therapeutic option to improve corneal wound healing.
Keywords
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Biochemistry
Authors
Y. Yang, H. Yang, Z. Wang, K. Varadaraj, S.S. Kumari, S. Mergler, Y. Okada, S. Saika, P.J. Kingsley, L.J. Marnett, P.S. Reinach,