Article ID Journal Published Year Pages File Type
1963648 Cellular Signalling 2011 8 Pages PDF
Abstract
► Suppression of Plk1 expression is dependent on p21Waf1. ► The p21Waf1-dependent suppression of Plk1 maintains damage-induced p53 activation. ► Expression of Plk1 disrupts the interaction of p53 with target gene promoters. ► Suppression of Plk1 is needed for p53-mediated inhibition of mitotic death.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Suppression of Polo like kinase 1 (PLK1) by p21Waf1 mediates the p53-dependent prevention of caspase-independent mitotic death
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