Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1964181 | Cellular Signalling | 2006 | 6 Pages |
Abstract
Type 2 diabetes mellitus is a multigenic disease with evident genetic predisposition, and complex pathogenesis in which environmental and genetic factors interact. The disorder of body utilization glucose is a crucial reason for causing diabetes. Atypical PKCs, belonging to Ser/Thr protein kinase, have many important biological functions in vivo, and may be involved in the pathogenesis of diabetes mellitus. APKCs participate in glucose metabolism by regulating glucose transport and absorption, glycogen synthesis, and insulin secretion. The exact mechanism by which aPKCs participate in glucose metabolism remains unclear. So far, the clarification of which will be helpful for the prevention and cure of type 2 diabetes.
Keywords
PI3KPar3PDK-1aPKCGLUT2phorbol 12-myristate 13-acetateGLUT4GSK-3PKCIRSeGFPPMAPar6Atypical PKCAkt/PKBinsulin receptor substrateCytoskeletal remodelingInsulin secretionglucose transporter 4diacyl glycerolDAGGlycogen synthesisPhosphatidylinositol 3-kinaseGlucose metabolismexercise3-phosphoinositide-dependent protein kinase 1protein kinase BProtein kinase CCaPglucose transporter 2insulin receptor
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Authors
Xiao-Jun Liu, Ai-Bin He, Yong-Sheng Chang, Fu-De Fang,