| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1964260 | Cellular Signalling | 2007 | 5 Pages |
Abstract
The effects of estrogen in breast epithelial cells are mediated primarily via estrogen receptor α and estrogen receptor β (ERα and ERβ). Accumulating evidence implicates a role for Ca2+ and calmodulin in breast carcinoma, as well as in the function of ERα. Calmodulin contributes to the regulation of both ERα degradation and ERα-mediated transcriptional activation. Recent data will be summarized in this review. Models to explain the molecular mechanisms by which calmodulin modulates ERα function are proposed.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Lu Li, David B. Sacks,