| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1964737 | Cellular Signalling | 2011 | 9 Pages |
Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.
Research highlights► Insulin activates Rac1 in muscle cells and mature skeletal muscle. ► Activation of Rac1 is required for insulin-mediated GLUT4 traffic to the cell surface. ► Rac-dependent actin reorganisation facilitates insulin-induced GLUT4 translocation. ► Rac activation becomes impaired during conditions of insulin resistance.
